Magnetic contaminations of small iron meteorites, Odessa and Gibeon

Small samples of Odessa iron meteorites and Gibeon iron meteorites were studied to assess any magnetic contaminations acquired after the meteorites reached the surface of the earth. Odessa showed a stable component of natural remanent magnetization (NRM) present during AF demagnetization up to 50mT. The NRM intensity decreased from one side to the other side with the exception of an interior sample. These variations in NRM might be acquired by artificial magnetic contamination, which is supported by the REM (the ratio of NRM to saturation isothermal remanent magnetization (SIRM)) value proposed by WASILEWSKI and DICKINSON (1998). The Gibeon\u27s subsample directions with stronger NRM intensities made one cluster and those weaker intensities clustered at a different site. According to the REM values, the more intense NRM\u27s might be the result of a magnetic contamination overprint. From these experimental subsamples analyses, from small iron meteorites, we find that the possibility of magnetic contamination must be considered during NRM analyses of meteorite magnetism

Thermal Infrared Imaging Experiments of C-Type Asteroid 162173 Ryugu on Hayabusa2

The thermal infrared imager TIR onboard Hayabusa2 has been developed to investigate thermo-physical properties of C-type, near-Earth asteroid 162173 Ryugu. TIR is one of the remote science instruments on Hayabusa2 designed to understand the nature of a volatile-rich solar system small body, but it also has significant mission objectives to provide information on surface physical properties and conditions for sampling site selection as well as the assessment of safe landing operations. TIR is based on a two-dimensional uncooled micro-bolometer array inherited from the Longwave Infrared Camera LIR on Akatsuki (Fukuhara et al., 2011). TIR takes images of thermal infrared emission in 8 to 12 μm with a field of view of 16×12∘ and a spatial resolution of 0.05∘ per pixel. TIR covers the temperature range from 150 to 460 K, including the well calibrated range from 230 to 420 K. Temperature accuracy is within 2 K or better for summed images, and the relative accuracy or noise equivalent temperature difference (NETD) at each of pixels is 0.4 K or lower for the well-calibrated temperature range. TIR takes a couple of images with shutter open and closed, the corresponding dark frame, and provides a true thermal image by dark frame subtraction. Data processing involves summation of multiple images, image processing including the StarPixel compression (Hihara et al., 2014), and transfer to the data recorder in the spacecraft digital electronics (DE). We report the scientific and mission objectives of TIR, the requirements and constraints for the instrument specifications, the designed instrumentation and the pre-flight and in-flight performances of TIR, as well as its observation plan during the Hayabusa2 mission

Influence of post-disaster evacuation on incidence of hyperuricemia in residents of Fukushima Prefecture: the Fukushima Health Management Survey

Aim: After the Great East Japan Earthquake, over 160, 000 residents in Fukushima Prefecture were forced to evacuate the area around the Fukushima Daiichi power plant following nuclear accident there. Health problems in these evacuees have since become a major issue. We have examined the association between evacuation and incidence of hyperuricemia among residents in Fukushima. Methods: We conducted a cohort study of residents aged 40–90 years without hyperuricemia at the time of the Fukushima disaster. Among 8173 residents who met the inclusion criteria before the disaster, 4789 residents (men: 1971, women: 2818; follow-up duration: 1.38 years; and follow-up rate: 58.6%) remained available for follow-up examinations at the end of March 2013. The main endpoint was incidence of hyperuricemia, defined by the Japanese committee guidelines, using local health data from before and after the disaster. We divided participants by evacuation status and compared outcomes between groups. Using a logistic regression model, we estimated the odds ratio for incidence of hyperuricemia, adjusting for potential confounders, age, gender, waist circumference, physical activity, and alcohol consumption. Results: Incidence of hyperuricemia was higher in evacuees (men 10.1%; women 1.1%) than in non-evacuees (men 7.4%, women 1.0%). Evacuees had higher body mass index, waist circumference, triglycerides, LDL-cholesterol, fasting plasma glucose, HbA1c, and lower HDL-cholesterol after the disaster than non-evacuees. We found that evacuation was associated with incidence of hyperuricemia (adjusted odds ratio: 1.38; 95% confidence interval: 1.03-1.86). Conclusion: This is the first study to demonstrate an association between evacuation after a disaster and increased incidence of hyperuricemia

Highly porous nature of a primitive asteroid revealed by thermal imaging

Carbonaceous (C-type) asteroids are relics of the early Solar System that have preserved primitive materials since their formation approximately 4.6 billion years ago. They are probably analogues of carbonaceous chondrites and are essential for understanding planetary formation processes. However, their physical properties remain poorly known because carbonaceous chondrite meteoroids tend not to survive entry to Earth’s atmosphere. Here we report on global one-rotation thermographic images of the C-type asteroid 162173 Ryugu, taken by the thermal infrared imager (TIR) onboard the spacecraft Hayabusa2, indicating that the asteroid’s boulders and their surroundings have similar temperatures, with a derived thermal inertia of about 300 J m−2 s−0.5 K−1 (300 tiu). Contrary to predictions that the surface consists of regolith and dense boulders, this low thermal inertia suggests that the boulders are more porous than typical carbonaceous chondrites and that their surroundings are covered with porous fragments more than 10 centimetres in diameter. Close-up thermal images confirm the presence of such porous fragments and the flat diurnal temperature profiles suggest a strong surface roughness effect. We also observed in the close-up thermal images boulders that are colder during the day, with thermal inertia exceeding 600 tiu, corresponding to dense boulders similar to typical carbonaceous chondrites. These results constrain the formation history of Ryugu: the asteroid must be a rubble pile formed from impact fragments of a parent body with microporosity of approximately 30 to 50 per cent that experienced a low degree of consolidation. The dense boulders might have originated from the consolidated innermost region or they may have an exogenic origin. This high-porosity asteroid may link cosmic fluffy dust to dense celestial bodies.Additional co-authors: Tsuneo Matsunaga, Takeshi Imamura, Takehiko Wada, Sunao Hasegawa, Jörn Helbert, Thomas G. Müller, Jens Biele, Matthias Grott, Maximilian Hamm, Marco Delbo, Naru Hirata, Naoyuki Hirata, Yukio Yamamoto, Seiji Sugita, Noriyuki Namiki, Kohei Kitazato, Masahiko Arakawa, Shogo Tachibana, Hitoshi Ikeda, Masateru Ishiguro, Koji Wada, Chikatoshi Honda, Rie Honda, Yoshiaki Ishihara, Koji Matsumoto, Moe Matsuoka, Tatsuhiro Michikami, Akira Miura, Tomokatsu Morota, Hirotomo Noda, Rina Noguchi, Kazunori Ogawa, Kei Shirai, Eri Tatsumi, Hikaru Yabuta, Yasuhiro Yokota, Manabu Yamada, Masanao Abe, Masahiko Hayakawa, Takahiro Iwata, Masanobu Ozaki, Hajime Yano, Satoshi Hosoda, Osamu Mori, Hirotaka Sawada, Takanobu Shimada, Hiroshi Takeuchi, Ryudo Tsukizaki, Atsushi Fujii, Chikako Hirose, Shota Kikuchi, Yuya Mimasu, Naoko Ogawa, Go Ono, Tadateru Takahashi, Yuto Takei, Tomohiro Yamaguchi, Kent Yoshikawa, Fuyuto Terui, Takanao Saiki, Satoru Nakazawa, Makoto Yoshikawa, Seiichiro Watanabe & Yuichi Tsud

Authentic role of ATP signaling in micturition reflex

Adenosine triphosphate (ATP) is a signaling molecule that regulates cellular processes. Based on previous studies of bladder function over the past decade, bladder ATP signaling was thought to have an essential role in the normal micturition reflex. In this study, we performed detailed analyses of bladder function in purinergic receptor-deficient mice using the automated voided stain on paper method and video-urodynamics. Unexpectedly, a lack of P2X2 or P2X3 receptors did not affect bladder function under normal physiological conditions, indicating that bladder ATP signaling is not essential for normal micturition reflex. In contrast, we found that lipopolysaccharide (LPS) induced markedly high levels of ATP release from the urothelium. In addition, LPS-induced rapid bladder hyperactivity was attenuated in P2X2 -/- and P2X3 -/- mice. Contrary to the previous interpretation, our present findings indicate that bladder ATP signaling has a fundamental role in the micturition reflex, especially in bladder dysfunction, under pathological conditions. Therefore, the bladder ATP signaling pathway might be a highly promising therapeutic target for functional bladder disorders. This study newly defines an authentic role for bladder ATP signaling in the micturition reflex

UNIFORM-1: First Micro-Satellite of Forest Fire Monitoring Constellation Project

UNIFORM Project had started in November 2010 with its vision of constructing sustainable micro-satellite constellation system via cooperation with various countries. International collaboration and actual utilization of the system are the keys of the project for realizing sustainable space industry. Forest fire monitoring was selected as the first mission. UNIFORM-1 is the first micro-satellite, weighing 50kg with 50cm cubic size, in this project and launched on May 24th, 2014 by H-IIA rocket as a secondary payload. UNIFORM-1 carries two cameras of area sensor: uncooled microbolometer camera and visible light camera. Both have GSD of less than 200[m] and swath is about 100km. These two cameras are used for localization of heat anomaly spots. The acquired image will be overlaid on global map to generate a “forest fire map” which will be released so that local fire department of the concerning country can take action promptly and extinguish forest fire. Other key features of this satellite are following: 3-axis control with reaction wheels, deployable solar array panel wings, lithium ion battery, and 10Mbps X-band transmitter for mission data. Design and test result of UNIFORM-1 flight model is explained in detail in this paper. As the result of initial operation of five days after launch, image of infrared camera was successfully acquired

Thermal inertia of asteroid Ryugu using dawn-side thermal images by TIR on Hayabusa2

A thermal inertia map of the C-type Near-Earth asteroid 162173 Ryugu has been derived using the one-rotation global thermal image sets observed from the Home Position at 20 km altitude [1]. This time the thermal images of the night side areas of the surface just before sunrise were taken during observations from the dawn side. The coldest brightness temperature of the surface indicates another information on the thermal inertia of the surface. The thermal inertia is preliminary estimated at 250 [J m-2K-1s-0.5] or lower, which is consistent with other than those derived from the daytime observations [2]

Mitochondrial Localization of ABC Transporter ABCG2 and Its Function in 5-Aminolevulinic Acid-Mediated Protoporphyrin IX Accumulation

Accumulation of protoporphyrin IX (PpIX) in malignant cells is the basis of 5-aminolevulinic acid (ALA)-mediated photodynamic therapy. We studied the expression of proteins that possibly affect ALA-mediated PpIX accumulation, namely oligopeptide transporter-1 and -2, ferrochelatase and ATP-binding cassette transporter G2 (ABCG2), in several tumor cell lines. Among these proteins, only ABCG2 correlated negatively with ALA-mediated PpIX accumulation. Both a subcellular fractionation study and confocal laser microscopic analysis revealed that ABCG2 was distributed not only in the plasma membrane but also intracellular organelles, including mitochondria. In addition, mitochondrial ABCG2 regulated the content of ALA-mediated PpIX in mitochondria, and Ko143, a specific inhibitor of ABCG2, enhanced mitochondrial PpIX accumulation. To clarify the possible roles of mitochondrial ABCG2, we characterized stably transfected-HEK (ST-HEK) cells overexpressing ABCG2. In these ST-HEK cells, functionally active ABCG2 was detected in mitochondria, and treatment with Ko143 increased ALA-mediated mitochondrial PpIX accumulation. Moreover, the mitochondria isolated from ST-HEK cells exported doxorubicin probably through ABCG2, because the export of doxorubicin was inhibited by Ko143. The susceptibility of ABCG2 distributed in mitochondria to proteinase K, endoglycosidase H and peptide-N-glycosidase F suggested that ABCG2 in mitochondrial fraction is modified by N-glycans and trafficked through the endoplasmic reticulum and Golgi apparatus and finally localizes within the mitochondria. Thus, it was found that ABCG2 distributed in mitochondria is a functional transporter and that the mitochondrial ABCG2 regulates ALA-mediated PpIX level through PpIX export from mitochondria to the cytosol